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Appendix 6 - Medicines not classified in the BNF – Imported or Unlicensed Products

These products are occasionally initiated in secondary care, but should only be used where other licensed conventional medicines are inappropriate, ineffective or not tolerated.  Most of the following preparations are unlicensed.

 

 

 

GREEN Light Drugs

Generic Name 

Brand Name 

Indication / Comments 

Formulary Link 

Carbaryl 0.2% Aqueous Liquid     13>10>4
Carbaryl 0.5% Alcoholic Lotion     13>10>4
Colecalciferol ProD3® brand only Unlicensed 9>6>4
Hydrocortisone & Clioquinol Cream/Ointment Vioform-Hydrocortisone®   13>4
Levomepromazine 6mg Tablets Nozinan® Unlicensed. 4>6
Magnesium Glycerophosphate 95mg Tablets   Unlicensed. 9>5>1>3
Neomycin & Hydrocortisone Eye drops Neo-Cortef®   11>4>1
Octenidine Skin Cleanser Octenisan®   13>11>5
Phenothrin 0.2% Alcoholic Lotion Full Marks®   13>10>4
Phenothrin 0.5% Aqueous Liquid Full Marks®   13>10>4
Potassium Citrate Tablets Urocit-K® Unlicensed.  7>4>3 
Roc Sante Soleil® UVB-SPF 25     13>8>1
       
Triple Care Cream®     13>2>2

 

 

 

AMBER Light Drugs

 Generic Name 

 Brand Name 

 Indication / Comments 

 Formulary Link 

Aminoglutethimide 250mg Tablets Cytadern®   8>3>3

Biotin 5mg Tablets 

(Vitamin B Complex)

  Unlicensed.  9>6>2 
Chlorothiazide 250mg in 5ml Suspension  Diuril®  Unlicensed.  2>2>1 
Clindamycin 75mg in 5ml Syrup    Unlicensed.  5>1>6 
Colesevelam Cholestagel® Off license use for intractable diarrhoea under specialsist gastroenterology guidance only  
Diltiazem 2% Cream Anoheal®

Unlicensed.

For Anal Fissures.

1>7>4 
Ethinylestradiol 2mcg Tablets    Unlicensed.  6>4>1>1 
Flunarizine 5mg & 10mg Tablets  Sibelium®  Unlicensed.  4>7>4>2 
Gelclair®     12>3>1
Ivermectin 3mg Tablets  Ivexterm®  Mectizan®  Stromectol® Unlicensed.  5>5 
Lactitol 10g Sachets  Importal®  Unlicensed.  1>6>4 
Magnesium Asparate Sachets Magnaspartate®   9>5>1>3
Nefazodone 200mg Tablets 

Nefadar® 

Serzone®

Unlicensed.  4>3>1 
Papaverine Injection Papacon®  Pavabid®  Pavacot®  Pavagen®

Unlicensed.

For Erectile Dysfunction.

7>4>5 
Phenobarbitone 50mg/5ml Oral Liquid  

Unlicensed.

For paediatric use only.

4>8>1
Phytomenadione 1mg Capsules Orakay® Unlicensed. 9>6>6 
Primaquine 15mg Tablets Malirid-DS

Unlicensed.

Named patient.

5>4>1
Propranolol tablets   Unlicensed use for portal hypertension  
Pyrazinamide   Tuberculosis 5>1>9
VSL#3 Probiotic   For adults with lactose intolerance, irritable bowel syndrome and inflammatory bowel disease link to guideline
Zonisamide   Off licence use in generalised epilepsy or focal epilepsy (SANAD II Trial)  

 

 

 

RED Light Drugs

Generic Name 

Brand Name 

Indication / Comments 

Formulary Link 

Acetylcysteine Capsules  Fluimucil®  NAC®  Unlicensed.  3>7 
Albendazole 400mg Tablets  Albenza®  Andazol®  Eskazole®  Zentel®  Unlicensed.   5>5 
Alemtuzumab MabCampath® Unlicensed for MS 8>2>4
Anatacid and Oxetacaine Suspension   Unlicensed special for treatment of  Painful swallowing, during/following radiotherapy to the head & neck and chest areas  
Benzathine Penicillin 1.2 & 2.4 mega unit Injection  Bicillin L-A®  Extencilline®  Penidural®  Retarpen® Unlicensed.   5>1>1>1 
Benzbromarone 50mg Tablets  Narcaricin® Unlicensed.   10>1>4 
Bismuth Iodoform Paraffin Paste on Gauze BIPP® on Gauze   12>2>3
Cantharidrin   Unlicensed 13>7
Chloramphenical eye ointment 1%  

Off licence use topically for wounds. Restricted to use by ENT and Maxillofacial.

 
Chlorhexidine diacetate 0.02% eye drops   Unlicensed - specialist use only 11>3>1
Ciclosporin eye drops 0.06% Moorfields Unlicensed - specialist use only - severe dry eyes 11>8>1
Ciprofloxacin eye drops   Off licensed use  for treatment of chronic otitis media and otitis externa  (necrotising) where pseudomonas is the commonest pathogen. Restricted to use by ENT.  

Co-Enzyme Q10

(Ubidecarenone)  

Lamberts brand 

Dr Rakshi.

For Mitochondrial disorders - unlicensed use of this dietary/healthfood supplement as recommended in the BNF for Children.  

9>8>1 

Colecalciferol 1,500iu in 1ml Oral Solution

Vitamin D3 

  Unlicensed.   9>6>4 
Deferiprone 750mg in 5ml Suspension Ferriprox® Unlicensed.  9>1>3
Dequalinium Chloride Lozenges Dequadin®   12>3>2
Dequalinium Chloride & Benzacaine Lozenges Dequacaine®   12>3>2
Diazoxide 50mg in 1ml Oral Suspension Proglycem Unlicensed 6>1>4
Dimethylfumurate (Fumaric Acid) 30mg & 120mg Tablets    Unlicensed.   13>5>2 

Dimethyl Sulphoxide Bladder Instillation

(DMSO) 

Rimso-50®  Unlicensed.   7>4>4 
Dolasetron 12.5mg in 0.625ml Injection Anzemet®  For post operative nausea and vomiting in adults (not licensed for use in children) - see PONV guidelines. 4>6
Fluspirilene 1.5mg in 0.75ml Injection 

Imap® 

Lopac-F-100®  Redeptin® 

Unlicensed.   4>2>2 
Fluspirilene 2mg in 1ml Injection 6ml 

Imap® 

Lopac-F-100®  Redeptin® 

Unlicensed.   4>2>2 
Folic Acid 15mg in 1ml Injection Folsan®  Unlicensed. 9>1>2 
       
Gentamicin Sponge  Collatamp G®    5>1>4 
Glycopyrronium   Unlicensed -hypersalivation in children  
Hexastarch Infusion eloHAES®   9>2>2>2
Humulin R 500unit/5mL Humulin R 500 unit/5mL Unlicensed.Import on named patient basis 6>1>1
Iloprost 0.1mg in 1ml  Ilomedin® 

Unlicensed. 

Only for use in severe Raynaud's phenomenon & other associated disorders. 

2>5>1 
Indocyanine green  

Unlicensed.

Only for use in assessment of pre-operative hepatic function prior to liver resection

 
Isoprenaline 100mcg in 1ml & 2mg in 1ml Injection Saventrine® Unlicensed. 2>7>1 
Ketamine Oral Solution    Unlicensed.   4>7>3 
Levamisole 50mg Tablets  Ergamisol®  Ketrax®  Solaskil® Unlicensed.   5>5 
Lidocaine 4%, adrenaline 0.1%, tetracaine 0.5% w/v LAT Gel®

Unlicensed. 

Wound anaesthesia in children <18 years

13>3
Melatonin 500mcg, 1mg, 3mg & 5mg Capsules Melapure®  Travelag® / Vytalonin® Unlicensed. 4>1>1
Methotrexate 20mg in 5ml Oral Solution    Unlicensed.  

1>5>3

8>1>3

10>1>3 

13>5>3

Methoxypsoralen 1.2% Bath Lotion 

Psoralen® 

8-MOP® 

Unlicensed.   13>5>2 
Methoxypsoralen 0.005% Gel 50g 

Psoralen® 

8-MOP® 

Unlicensed.   13>5>2 
Methoxypsoralen 10mg & 20mg Tablets 

Psoralen® 

8-MOP® 

Unlicensed.   13>5>2 
Mexiletine  

Unlicensed.

Consultant use only

2>3>2
Midodrine Hydrochloride 2.5mg Tablets  Amatine®  Gutron®  Midon®  ProAmatine® 

Unlicensed. 

 

Nitrogen Mustard Cream

(Mechlorethamine / Mustine) 

Mustargen® 

Unlicensed. 

Discuss application in Primary Care with ELHT medicines information. 

13>8>1 
Oxandrolone 2.5mg Tablets  Anavar®  Oxandrin®  Unlicensed.   6>4>3 
Oxybutynin 5mg in 30ml Intravesical Solution    Unlicensed.   7>4>4 
Oxymetholone 50mg Tablets  Anadrol®  Anapolon® Unlicensed.   9>1>3 
Patent Blue V Sodium 2.5% Injection 2ml    Unlicensed.    
Pentosan Polysulphate 100mg Capsules  Elmiron®  Unlicensed.   7>4>4
Peppermint Water     1>2
Potassium Canrenoate Injection Soldactone®  Spiroctan-M® 

Unlicensed.

For NICU use only.

2>2>3
Praziquantel 500mg Tablets  Biltricide®  Cisticid®  Cysticide® Unlicensed.   5>5 
Primaquine 7.5mg Tablets  Malirid®  Unlicensed.   5>4>1 
Probenecid 500mg Tablets  Benemid®  Benuryl®  Probecid® Unlicensed.   10>1>4 
Procaine 0.5% Epidural Injection  Novocaine® 

Unlicensed.

Dr Mitchell - For use in the MSK service only.  

 

Riboflavin

Vitamin B2 

Lamberts brand  Dr Rakshi.  9>6>2 
Rose Bengal 1% Eye Drops Minims® Rose Bengal  Unlicensed. 11>8>2 
Scleremo® Injection    Unlicensed.   2>13 
Sildenafil 25mg Viagra® Unlicensed use in severe primary or secondary Raynaud’s resistant to initial therapies 2>6>4
Sodium Hyaluronate 40mg in 50ml Intravesical Instillation Cystistat® Unlicensed. 7>4>4
Spironolactone   Unlicensed - refractory adult female acne vulgaris resistant to multiple oral antibiotics & isotretinoin - consultant dermatologist use only  
Stanozolol 2mg Tablets  Winstrol®  Unlicensed.   6>4>3 
Streptomycin 1g Injection    Unlicensed.   5>1>9 

Sterptomycin 1g injection

 

 

 

 

 

  Unlicensed - specialist use - Madura foot  
Succimer Capsules  Chemet®  Unlicensed.    
Succinated gelatin Gelofusine® Unlicensed use by endoscopy - Direct injection into mucosal layer under polyp prior to endoscopic mucosal resection (EMR)  
Sucralfate  Gastric & duodenal ulcers Unlicensed use  1>3>3
Sulphamethoxypyrazinamide 500mg Tablets    Unlicensed.    
Sulthiame   Unlicensed - specialist use only  
Talc - Sterilised 4g    Unlicensed.   
Tiopronine 250mg Tablets  Acadione®  Captimer®  Thiola®  Unlicensed.    
Transvasin® Transvasin® Unlicensed. 10>3>2
Urokinase 25,000iu Injection  Syner-KINASE®  Ukidan®  Unlicensed.   2>10>2 

 

 

 

All material in this section is aimed at health professionals, but is information currently held within the public domain.   Members of the public seeking advice on medicine-related matters are encouraged to speak with their GP, pharmacist or nurse, or contact NHS Direct on 0845 46 47. 

Richard Lee, East Lancashire Health Economy New Drugs Pharmacist.

Email: Interface@bwd.nhs.uk

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